Immunomorphological signs of chronic endometritis in patients after failed attempts of auxiliary reproductive technologies

The objective: to analyze the morphological and immunohistochemical features of endometrium in patients with chronic endometritis after unsuccessful attempts assisted reproductive technologies (ART). Materials methods. A prospective study was conducted women a history on basis Medical Center LLC “ISIDA-IVF” for period from 2019 2021. I group included 55 age repeated ART, control (CG) – 40 without fertility disorders who are preparing replacement motherhood programs or oocyte donors. results endometrial biopsy performed 5–7th 19th–21st days menstrual cycle using pipelle aspiration curette were studied assessment immunomorphological characteristics endometritis. immunoperoxidase method primary specific monoclonal antibodies used estrogen progesterone receptors. Differences at p<0.05 considered statistically significant. Results. Pathomorphological revealed characteristic signs inflammation presence large number plasma cells stroma, lymphoid infiltrates near blood vessels gland orifices, unevenly expressed stroma fibrosis, sclerotic changes walls spiral arteries. All examined persons had two more (CE). An increase macrophages monocytes glands found by CE 31.3±2.9 % versus 2.3±0.1 CG (р<0.05). proliferative activity epithelium 5-7th day compared similar indicators secretion phase determined. proliferation glandular stromal cells, detected cycle, intensification programmed cell death process covering endometrium. This characterized structural nuclei marginal state chromatin, appearance karyorrhexis karyopyknosis. In capillary-type found, intensity their development strong correlation degree severity inflammatory (r=0.74; p<0.05). During receptors mainly decrease level expression both healthy - H-score 145.5±7.7 55.5±10.4 Conclusions. Immunomorphological demonstrates that tissues have clear criteria, which most pronounced sclerosis vessel walls, These persist secretory significant manifestations form